Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity / Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy McCann, Andy Noble, Maureen Walsh ... więcej

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity / Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy McCann, Andy Noble, Maureen Walsh // Journal of Inorganic Biochemistry [Dokument elektroniczny]. – 2009, Vol. 103, Iss. 9, s. 1196-1203 : rys., tab. – Tryb dostępu: http://www.sciencedirect.com/science/article/pii/S0162013409001184. – Bibliogr. 72 poz., Abstr. – doi: 10.1016/j.jinorgbio.2009.05.017. – ISSN 0162-0134

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper(II) ... więcej

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.