Polymer-ceramic biocomposites based on PVP/histidine/hydroxyapatite for hard tissue engineering applications / Agnieszka Sobczak-Kupiec, Agnieszka Maria Tomala, Cristina Domínguez López, Anna Drabczyk, ... więcej

Polymer-ceramic biocomposites based on PVP/histidine/hydroxyapatite for hard tissue engineering applications / Agnieszka Sobczak-Kupiec, Agnieszka Maria Tomala, Cristina Domínguez López, Anna Drabczyk, Bożena Tyliszczak // International Journal of Polymeric Materials and Polymeric Biomaterials [Dokument elektroniczny]. – 2021, Article in press, 13 s. : fot., tab., wykr. – Tryb dostępu: https://www.tandfonline.com/doi/full/10.1080/00914037.2021.1963725. – Bibliogr. 31 poz., Abstr. – doi: 10.1080/00914037.2021.1963725. – e-ISSN 1563-535X

Polymer and hydroxyapatite (HAP) composites have growing interest in bone regeneration. Commonly used for these applications is polyvinylpyrrolidone (PVP), which represents excellent biological inertness, ... więcej

Polymer and hydroxyapatite (HAP) composites have growing interest in bone regeneration. Commonly used for these applications is polyvinylpyrrolidone (PVP), which represents excellent biological inertness, is biocompatible, and do not adversely interact with HAP. For this reason, in our studies, we have focused on 3-igreedient biocomposites based on PVP/histidine/HAP investigating their mechanical performance, morphology, swelling property and incubation response. The objective is to determine the effect of histidine on the UV cross-linked hydroxyapatite-polymers composites particularly focused on the role of their composition on structure, mechanical properties, and biocompatibility. The results confirm bioactivity of this material and it desirable features for orthopedics.