The effect of glycerin content in sodium alginate/Poly(vinyl alcohol)-based hydrogels for wound dressing application / Katarzyna Bialik-Wąs, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna ... więcej

The effect of glycerin content in sodium alginate/Poly(vinyl alcohol)-based hydrogels for wound dressing application / Katarzyna Bialik-Wąs, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz // International Journal of Molecular Sciences [Dokument elektroniczny]. – 2021, Vol. 22, Iss. 21, Spec. Iss., 18 s. : fot., tab., wykr. – Tryb dostępu: https://www.mdpi.com/1422-0067/22/21/12022/htm. – Oznaczenie ref./art.: 12022. – Bibliogr. 58 poz., Abstr. – Special Issue: Novel Biomaterials for Wound Healing. – doi: 10.3390/ijms222112022. – ISSN 1661-6596

The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation ... więcej

The impact of different amounts of glycerin, which was used in the system of sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel materials on the properties, such as gel fraction, swelling ability, degradation in simulated body fluids, morphological analysis, and elongation tests were presented. The study shows a significant decrease in the gel fraction from 80.5 ± 2.1% to 45.0 ± 1.2% with the increase of glycerin content. The T5 values of the tested hydrogels were varied and range from 88.7 ◦C to 161.5 ◦C. The presence of glycerin in the matrices significantly decreased the thermal resistance, which was especially visible by T10 changes (273.9 to 163.5 ◦C). The degradation tests indicate that most of the tested materials do not degrade throughout the incubation period and maintain a constant ion level after 7-day incubation. The swelling abilities in distilled water and phosphate buffer solution are approximately 200–300%. However, we noticed that these values decrease with the increase in glycerin content. All tested matrices are characterized by the maximum elongation rate at break in a range of 37.6–69.5%. The FT-IR analysis exhibits glycerin changes in hydrogel structures, which is associated with the cross-linking reaction. Additionally, cytotoxicity results indicate good adhesion properties and no toxicity towards normal human dermal fibroblasts.