Chitosan nanoparticles : a potential biomedical device / Karolina Jafernik, Magdalena Anna Malinowska, Katarzyna Bialik-Wąs, Marta Sharafan, Halina Ekiert, Elźbieta Sikora and Agnieszka Szopa // W: Chitosan ... więcej

Chitosan nanoparticles : a potential biomedical device / Karolina Jafernik, Magdalena Anna Malinowska, Katarzyna Bialik-Wąs, Marta Sharafan, Halina Ekiert, Elźbieta Sikora and Agnieszka Szopa // W: Chitosan nanocomposites : bionanomechanical applications / eds. Sarat Kumar Swain, Anuradha Biswal. – Singapore : Springer, 2023. – (Biological and Medical Physics, Biomedical Engineering, ISSN 1618-7210). – S. 135-159 : rys. – Bibliogr. 66 poz., Abstr. – doi: 10.1007/978-981-19-9646-7_6. – ISBN 978-981-19-9645-0. – ISBN 978-981-19-9646-7 (eBook). – ISBN 978-981-19-9648-1 (Softcover)

Chitosan nanoparticles (chitosan-based nanoparticles; chitosan nanostructures; ChNPs) constitute a very interesting and promising group of bio-based compounds, which have attracted a lot of attention in ... więcej

Chitosan nanoparticles (chitosan-based nanoparticles; chitosan nanostructures; ChNPs) constitute a very interesting and promising group of bio-based compounds, which have attracted a lot of attention in the last decades. They are more and more commonly used in various biomedical devices, especially in cancer diagnostics (fluorescent endoscopic diagnostics, detecting cancer cells), wound dressings, as the glucose detection sensor and the histamine biosensor, in bone tissue engineering and dentistry, which are presented in details in this chapter. Such a variety of application possibilities is mainly due to the properties of chitosan, which is characterized by high biocompatibility, biodegradability, non-toxicity, as well as the great potential as nanocarriers encapsulating active substances and providing a controlled release process. This chapter presents an overview of ChNPs preparation methods, mainly: reversed micelles, emulsification and crosslinking, SCASA, spray drying, phase inversion precipitation, ionic gelation, and emulsion-droplet coalescence. Offering a lot of benefits, nanotechnology for medical and biomedical science has become the foundation for the development and improvement of human life. The safety of nanoparticles which can be toxic to the environment, organisms, and cells, had to be taken into account in their safety assessment in the biomedical fields. According to this, the overall safety of these materials is also evaluated.