Release study of selected terpenes from nanostructured lipid carriers / Elwira Lasoń, Elżbieta Sikora, Jan Ogonowski, Małgorzata Tabaszewska, Łukasz Skoczylas // Colloids and Surfaces A: Physicochemical ... więcej

Release study of selected terpenes from nanostructured lipid carriers / Elwira Lasoń, Elżbieta Sikora, Jan Ogonowski, Małgorzata Tabaszewska, Łukasz Skoczylas // Colloids and Surfaces A: Physicochemical and Engineering Aspects [Dokument elektroniczny]. – 2016, Vol. 510, s. 87-92 : fot., tab., wykr. – Tryb dostępu: http://www.sciencedirect.com/science/article/pii/S0927775716304630. – Bibliogr. 39 poz., Abstr. – Mat. konf.: 29th European Colloid and Interface Society conference (29th ECIS 2015), Bordeaux, 6-11.09.2015. – doi: 10.1016/j.colsurfa.2016.06.021. – ISSN 0927-7757

The main objective of this study was to evaluate the potential of nanostructured lipid carriers (NLC) as a delivery system for mono- (geranic acid), di- (forskolin) and triterpenes (ursolic acid). The ... więcej

The main objective of this study was to evaluate the potential of nanostructured lipid carriers (NLC) as a delivery system for mono- (geranic acid), di- (forskolin) and triterpenes (ursolic acid). The influence of the actives chemical structure on their release profile were investigated along with the physicochemical properties of terpene-loaded NLC. The formulations were prepared by ultrasound homogenization method using modified beeswax as a solid lipid and caprylic/capric trigliceryde as a liquid lipid. The systems were stabilized by alkylopolyglucoside. The average particle size for formulations with geranic acid (NLCGA), forskolin (NLCF) and ursolic acid (NLCUA) was 101.1 ± 0.4, 106.4 ± 1.4 and 97.6 ± 0.9 nm, respectively. In vitro release studies of the terpenes were performed at the 32 °C, using cellulose membrane (Spectra/Por® Dialysis Membrane) and PBS/ethanol mixture as a receptor solution. The obtained results confirmed a high physical stability of the formulations and showed that the achieved systems are suitable carriers for all, mono- di- and triterpenes.