Physicochemical evaluation of L-ascorbic acid and Aloe vera-containing polymer materials designed as dressings for diabetic foot ulcers / Magdalena Kędzierska, Mateusz Jamroży, Sonia Kudłacik-Kramarczyk, ... więcej

Physicochemical evaluation of L-ascorbic acid and Aloe vera-containing polymer materials designed as dressings for diabetic foot ulcers / Magdalena Kędzierska, Mateusz Jamroży, Sonia Kudłacik-Kramarczyk, Anna Drabczyk, Magdalena Bańkosz, Piotr Potemski, Bożena Tyliszczak // Materials [Dokument elektroniczny]. – 2022, Vol. 15, Iss. 18, Spec. Iss., 19 s. : rys., tab., wykr. – Tryb dostępu: https://www.mdpi.com/1996-1944/15/18/6404. – Oznaczenie ref./art.: 6404. – Bibliogr. 41 poz., Abstr. – Special Issue: Bioactive Materials and Advanced Biomedical Hydrogels in Medicinal Chemistry. – doi: 10.3390/ma15186404. – ISSN 1996-1944

Hydrogels belong to the group of polymers that are more and more often considered as innovative dressing materials. It is important to develop materials showing the most advantageous properties from the ... więcej

Hydrogels belong to the group of polymers that are more and more often considered as innovative dressing materials. It is important to develop materials showing the most advantageous properties from the application viewpoint wherein in the case of hydrogels, the type and the amount of the crosslinking agent strongly affect their properties. In this work, PVP-based hydrogels containing Aloe vera juice and L-ascorbic acid were obtained via UV-induced polymerization. Next, their surface morphology (via both optical, digital and scanning electron microscope), sorption capacity, tensile strength, and elongation were characterized. Their structure was analyzed via FT-IR spectroscopy wherein their impact on the simulated body liquids was verified via regular pH and temperature measurements of these liquids during hydrogels’ incubation. It was demonstrated that as the amount of the crosslinker increased, the polymer structure was more wrinkled. Next, hydrogels showed relatively smooth and only slightly rough surface, which was probably due to the fact that the modifiers filled also the outer pores of the materials. Hydrogels demonstrated buffering properties in all incubation media, wherein during the incubation the release of Aloe vera juice probably took place as evidenced by the decrease in the pH of the incubation media and the disappearance of the absorption band deriving from the polysaccharides included in the composition of this additive. Next, it was proved that as the amount of the crosslinker increased, hydrogels’ crosslinking density increased and thus their swelling ratio decreased. Hydrogels obtained using a crosslinking agent with higher average molecular weight showed higher swelling ability than the materials synthesized using crosslinker with lower average molecular weight. Moreover, as the amount of the crosslinking agent increased, the tensile strength of hydrogels as well as their percentage elongation also increased.